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If the hematopoietic stem cell undergoes any kind of DNA modification, such as methylation, microRNAs, double-strand breaks, or DNA breaks or damage, it is known as a hematopoietic stem cell muta.

However, clonal hematopoiesis, defined as multi-lineage hematopoietic cells of more than one hematopoietic lineage derived from a single stem cell, or clonal hematopoietic progenitors can occur in non-cancer contexts, such as physiological or stress-induced hematopoiesis. Likewise, leukemogenic retroviral infections can cause the emergence of such genetic changes in bone marrow multipotent hematopoietic cells in vivo, in young individuals who may not yet have symptoms of leukemia or other myeloid disorders. In addition, the concept of clonal hematopoiesis was recently expanded to include low-level somatic mutations within the blood cells of healthy individuals, and is currently proposed as a shifting paradigm of chronic transfusion therapy, and as a new cause of blood disorders such as myelodysplastic syndrome and fibrosis, especially in patients who have undergone cytoreductive allogeneic stem cell transplantation [11]. d2c66b5586

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