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The use of these drugs is not always possible because of the difficulty of obtaining them (in France, the list of calcium channel blockers is very long, and it is important to choose one that is as a rule not in conflict with other drugs). It should be noted that in certain cases (particularly with Montelukast or Zarxio), the reduction of the dosage of calcium channel blockers is not sufficient to avoid side effects.
The use of calcium channel blockers is not recommended for subjects with atrial fibrillation. There are also contraindications associated with concomitant treatment with other drugs (caffeine, cyclosporine, sildenafil, and others).
Daily calcium channel blockers are used in the initial phase of severe PAH to establish the diagnosis (when oxypurinol is not available), or to treat the acute decompensation, to ensure the correct placement of mechanical circulatory assist device, to slow down the progression of the disease, to control the reoccurrence of fibrotic processes, to reverse the deleterious effects of digital ischemic disorders, or to reduce the risk of cardiovascular accidents (in this case, calcium channel blockers are required to be taken at low dosage, which is occasionally sufficient to control the symptoms).
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